杜仲的快速毒性筛选试验

doi:10.3969/j.issn.1004-616x.2004.06.012

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2004, Vol. 16 ›› Issue (6): 355-358.doi: 10.3969/j.issn.1004-616x.2004.06.012

Previous Articles Next Articles

A Rapid Toxic Screening Experiment on Duzhong

SUI Hai-xia, GAO Peng, XU Hai-bin, et al

National Institute of Nutrition and Food Safety,China CDC, Beijing 100021, China

Received:2004-02-14 Revised:2004-06-20 Online:2004-11-30 Published:2004-11-30
Contact: SUI Hai-xia

Abstract

Abstract: BACKGROUND ＆ AIM： Although Duzhong was listed on the function food roll, there was lack of data of systematic toxic/safety evaluation experiments. MATERIAL AND METHODS： Safety evaluation experiment was done using acute toxicity experiment, cell toxicity experiment and genetic toxicity experiment . RESULTS： CHL and CHO were 109.38 mg/ml;it was negative in toxicity. CONCLUSION: It was found that Du zhong was a non-toxic substance and was negative in genetic toxicity,although it had some toxic effect on the CHO and CHL cell at higher dose levels.

Key words: Duzhong, acute toxicity, genetic toxicity

SUI Hai-xia, GAO Peng, XU Hai-bin, et al. A Rapid Toxic Screening Experiment on Duzhong[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2004, 16(6): 355-358.

[1]	SHI Wenjing, ZHANG Jiqianzhu, ZHU Jiangbo, ZHANG Xiaofang, WANG Ruina, DAI Xiaoyu, REN Lijun, TIAN Yijun. Evaluation of genotoxicity of diphenhydramine hydrochloride and caffeine compound [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(2): 149-153,157.
[2]	YANG Yu, HUANG Yali, LIN Fei, TANG Long. Acute toxicity and genotoxicity of antitumor serum thymic factor 9 peptide [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 57-61.
[3]	XIA Qiyue, YUE Qianlan, DOU Jiexiong, ZHUANG Siqi, LIU Keliang. Toxicological test of orally administered sodium sulfide in rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2022, 34(1): 62-66.
[4]	GE Xianmin, LI Bin, HUANG Chaopei, GAO Yuqiu, LUO Hailan, YANG Hui, WANG Yanwu, WEN Pingjing, LAN Guanghua, CHEN Huanhuan, MENG Qin, LUO Liuhong, DENG Yueqin, LIU Shuaifeng, WU Xiuling. Acute oral toxicity and mutagenicity of combined drugs for anti HIV [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(6): 466-469,474.
[5]	HUANG Chaopei, QIN Huiyan, ZHANG Lujuan, WANG Yanwu, HE Li, FU Weizhong. Study on acute toxicity and mutagenicity of Aronia melanocarpa extract in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 474-476.
[6]	LI Ruowan, ZHOU Changhui, HUANG Pengcheng, CHANG Yan. Establishment of an in vitro PIG-A gene mutation assay based on TK6 cells for genotoxicity tests [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2019, 31(3): 242-248.
[7]	XIA Ying, FU Shaohua, ZHANG Yinjing, WANG Wei. Genetic toxicity test of a pesticide, Paichongding [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2018, 30(2): 136-139.
[8]	CHEN Xiujuan, LIU Xiangmei, PANG Zengxiong, LIU Donghong, LIU Ying, LUO Xuelian, CHEN Hanjin, HUANG Yufeng. Acute and genetic toxicity of aqueous extract of Eriobotrya japonica leaves [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(5): 403-406.
[9]	YING Jian, HAO Binxiu, MENG Qingjia, CHEN Ran, WANG Liming, WANG Chunling. Acute toxicity and genotoxicity of crude water extracts from tea mistletoe Viscum Liquidambaricolum Hayata [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 306-309,324.
[10]	LUO Xueting, CAI Qijun, ZHAO Bo, CHEN Weimin, CHEN Xiao, ZHANG Xiaowen. Evaluation of acute and genetic toxicity of Zihe herbal solid beverage in mice [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(4): 302-305.
[11]	SU Bin, FU Yong, HOU Xiaodong, ZHANG Chaoying, LIANG Hui. Toxicity evaluation of tobacco seed oil [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 60-65.
[12]	TANG Jiao, ZHAO Min, YANG Ying, LI Qing, HUANG Junming, YANG Xingfen. Study on acute toxicity and mutagenicity of Panaxnotoginseng [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2016, 28(1): 66-68,72.
[13]	WANG Ying, PU Jiang, QI Naisong, WEN Hairuo, WANG Xin, HU Yanping, SONG Jie, ZHANG Joe, WANG Xue. A high-throughput screening method and application of cell transformation assay in Bhas 42 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(4): 288-293.
[14]	BAO Jie, WEI Jinfeng, WANG Xiaoliang, LI Haiyan, ZOU Na, WANG Aiping. Studies on acute toxicity and mutagenicity of potassium 2-(1-hydroxypentyl)-benzoate [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 137-141.
[15]	ZHONG Yuting, JIA Zhenchao, YAN Jiuming, LUO Sha, LU Yedan, ZHANG Lishi. Study of acute toxicity and mutagenicity of bamboo charcoal powder [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2015, 27(2): 142-145.

A Rapid Toxic Screening Experiment on Duzhong

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments